Download seminar poster
Talk Title :
Reconstructing gene networks by epistatic analysis of phenotype and expression data
Date / Time / Location:
Thursday October 8th, 2009 - 6:00 pm
McGill University
Room 232, Leacock Building
855 Sherbrooke Street West
Affiliation :
Ottawa Institute of Systems Biology
URL
Mads Kaern
Abstract :
One the most successful methods to map genetic networks and pathways predates modern genomics by nearly a century. This method, epistatic analysis, traditionally involves observing the phenotypic impact of mutating two different genes individually and in combination. This talk will introduce the basic concepts involved and discuss recent advances emphasizing the inference of transcriptional regulatory networks. In one study, we investigated if conventional epistatic analysis might be used to highlight interactions within the network regulating the transcriptional response of yeast to DNA damage, and developed a method to specifically identify dynamically modulated functional relationships. Somewhat surprisingly, the network derived from phenotypic data has only a modest overlap with that inferred from microarray data. In a second study, we directly compared epistatic analysis based on phenotypic data and marker gene expression. This analysis demonstrates that the two approaches provide complementary information. While conventional analysis correctly infers the order of genes in metabolic pathways, expression-based analysis specifically highlight regulatory hierarchies. Moreover, combining the two methods allows for a nearly complete network reconstruction with a negligible false discovery rate.
MonBUG 2nd year launch symposium
- Thursday September 3rd, 2009
In order to start it’s activities on the right foot, MonBUG has decided the first activity of it’s second season would be a one-day symposium featuring invited and local speakers as well as student speakers selected on the basis of the quality of their presented posters
Download the symposium poster
Here is the current schedule for the meeting:
| 8h00-8h30 |
Set-up posters |
| 8h30-8h45 |
Welcome
Tarik Möröy
President and Scientific Director
Institut de recherches cliniques de Montréal (IRCM) |
| 8h45-9h00 |
Opening words
Ken Dewar
Acting Scientific Director
McGill University and Génome Québec Innovation Centre |
Keynote I
|
| 9h00-10h00 |
Fulfilling the Promise of a Sequenced Human Genome
Eric Green
Director, NIH Intramural Sequencing Center |
| 10h00-10h30 |
Coffee break |
Session I
Chair: Mathieu Blanchette
|
| 10h30-11h00 |
Discovering INDEL and Copy Number Genomic Variation from Paired Reads
Michael Brudno
University of Toronto |
| 11h00-11h30 |
Genome-wide Discovery of Trancript Isoform Variants
Jacek Majewski
McGill University |
| 11h30-12h00 |
The Mammalian Early Development: Comparing Apples and Oranges
Claude Robert
Université Laval |
| 12h00-12h15 |
Sequence and Structural Variation in a Human Genome
Heather Peckham
ABI sponsored scientific presentation |
| 12h15-12h30 |
GPU Computing Implementation of a Quaternary Tree for Fast Identification of Genes and Genomes in High Throughput Sequence Analysis
Fouad Boumezbeur
Sciences de la vie — Université PARIS VII |
Poster Session I
|
| 12h30-14h00 |
Lunch and concurrent poster session |
Session II
Chair: Raphaël Gottardo
|
| 14h00-14h30 |
Modeling Structural Ensembles of Transmembrane Proteins
Jérome Waldispühl
Massachusetts Institute of Technology |
| 14h30-15h00 |
Proteomics and Lipidomics Studies of the Brain
Daniel Figeys
University of Ottawa |
| 15h00-15h30 |
Informatics of Cinematics; Quantifying Mitosis in Living Cells
Paul Maddox
IRIC / Université de Montréal |
| 15h30-15h45 |
Using Next-Generation Genome Sequencing Technologies to Examine Genome Change and Virulence in Malaria Parasites
Martine M. Zilversmit
CHU Ste-Justine — Université de Montréal |
| 15h45-16h15 |
Coffee break |
Keynote II
|
| 16h15-17h15 |
Discovering Genomic Variation in Cancer Genomes
Elaine Mardis
Co-Director, WUSTL Genome Sequencing Center |
| 17h15-17h30 |
Closing comments
Speaker: to be announced |
Poster Session II
|
| 17h30-… |
Wine and cheese and concurrent poster session |
| 18h30-19h00 |
Take down posters |
Proud symposium sponsors:
Mads Kaern